NSTE-ACS was diagnosed according to the following criteria: typical chest pain and/or electrocardiographic changes without new ST elevation indicating myocardial ischemia with negative or elevated cardiac enzymes. The diagnosis of ACS was based on the criteria of the Joint European Society of Cardiology/American College of Cardiology Foundation/American Heart Association/Word Heart Federation Task definition ( 13). Thus, the aim of the current study was to investigate whether high GRS and TRI are associated with the extent and severity of CAD in patients with ACS. However, although a number of studies have investigated the relationship between GRS, TRI, and CAD ( 11, 12), none has addressed the association between GRS, TRI, and the severity of CAD assessed by SS in patients with ACS. This index has been shown in many studies to be useful and helpful ( 9, 10). Recently, the TIMI risk index (TRI) has been improved and is able to predict mortality, is easier to assess, and can perform scoring with fewer parameters (age, blood pressure, and heart rate, etc.) in patients with NSTE-ACS and patients with STEMI. The prediction of early and late mortality with the GRACE risk score and TIMI risk score has been used for testing populations of hundreds of thousands of patients. In order to identify high-risk patients with ACS, various risk classification systems and scoring systems are quite frequently used ( 3- 8). Therefore, those interested in cardiovascular medicine still need an easily accessible, cost-effective, and noninvasive method to carry out risk stratification by determining the extent and severity of CAD in ACS patients. Although these scoring systems have many advantages, they require an invasive method, such as coronary angiography, to perform the scoring. The SYNTAX score (SS) is one of the scoring systems for determining the extent and severity of CAD ( 2). For this purpose, a large number of scoring systems and laboratory parameters have been used in clinical practice. Recently, one of the major issues cardiologists have addressed is risk stratification in patients with ACS, in order to identify the severity and complexity of coronary artery disease (CAD). ![]() ACS includes non-ST elevated ACS (NSTE-ACS) and ST elevated myocardial infarction (STEMI). ![]() Acute coronary syndrome (ACS) is a significant cause of morbidity and mortality in patients with coronary heart disease in developed countries ( 1).
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